Death to the Leathermans! Gerber akbar!

Well, I don't have much experience with the newer Leathermans. My kid brother has one with funny thumb-wheel blade locks, which hurt my thumbs. My dad has a Wave, which is OK, but the thing I like about the Gerber is the one-handed opening of the pliers. For me, the knife blade is probably the least-used tool on the Gerber. If I need a knife, I pull out one of my three folders, according to the task at hand. The Gerber's blade is half-serrated, which is occasionally useful, but usually one of my knives is a better fit. Since you didn't mention carrying a slew of knives, perhaps you're better off with something like the Charge, with handier knife blades and less handy pliers.

That said, I'm real happy with my Gerber (Pro-Scout 600). I like the file and scissors; both are the best I've seen in a multi-tool. The saw is nice, too: it holds a standard 1/4" jigsaw blade. Comes with a carbide grit blade, but you can get blades of all varieties at your local hardware store.
Grip is quite comfortable because of the way the sheetmetal is formed. The locks aren't the greatest in the world, but do the job.

One great thing about the Gerber is that, with a pair of pliers, you can adjust the tension, or even disassemble the pivots. Then, you can rearrange the tools that are there, swap them with other Gerbers, or replace them with your own. A hack-friendly multi-tool!

My main complaint with the Gerber is that the nylon sheath doesn't hold up well because of the way the tip of the pliers protrudes. It gets a hole in the bottom of the sheath after a couple months of belt carry. The pliers can also prematurely wear out pants pockets, if carried tip-down. I now carry it tip-up, and no more problems.