And you are sure speedpatch uninstalls correctly? No remnants? Anyway we are still trying to discover what are the best settings to be used with compcache.
For now you may try (in xterm as root)

echo 20 > /proc/sys/vm/swappiness
echo 2 > /proc/sys/vm/page-cluster

hoping that other vm settings are stock. if that not help then I can bet you have some remnants from some optimization script that have messed your /proc/sys/vm/ (and who knows what else) values. In case lagging continues would you please do cat /proc/sys/vm/* and copy the result here