it is most certainly possible, however many programs do not run (old wine) and nptl is not supported so only old versions of wine work. Give it a shot though, it is great, i run it on my n900
http://talk.maemo.org/showthread.php?t=43480&page=11
start reading on from there, i believe the tutorial on that page is not the right one, its the one with a wine.tar.gz