I hope it is not off-topic here, as it is mean to increase uptime without lags - using swap on microSD (even class 2) and re-enabling it after total amount of data written to swap partition exceeds 600 (*not* data currently on swap, but data written totally, check iostat), result in absolutely 0 negative effects of long uptime.

Using the above (re-swapping by semi-automatic script that I've based on shadowjk's work) I used to get uptimes like 30 days (sic!) without any negative effect on performance (used, because now I'm installing/tweaking etc. things, that many times require reboot to take effect).

Yet, it is interesting catch about vacuuming databases. If confirmed to not bring risk of corrupting anything (in some particular cases of execution time), it may be nice addition to reswapping.

/Estel