I'm not entirely sure; I'm using Qt for my interface, but I'm no expert on the workings of Qt. I'm using their most basic button widgets laid out mostly in a series of grids on a tabbed window. I really don't know just how much can be done to change the contents of the GUI.

Now, on the other side, I have absolutely no problem remapping those buttons to new functions, as you can tell whenever you change keysets. That part is easy. I just don't know enough GUI workings to change labels or icons or button layouts on the fly...