I'm on vanilla CM9 now. CM10 (both vanilla and PA1.99) appeared to have some chronic memory leak which required either a forced reboot daily, or diligint rebooting in the morning to ensure it didn't happen.

With this, I'm using

• Hackers Keyboard - with full keyboard setting on landscape and 5 row gingerbread on portrait
• Markers - for scribbling and quickly sending stuff
• Memo Beta to replace S-Memo - note, this includes S-pen functionality. Note there is also a homebrew called G-Note available on the note forums on xda, but I prefer memo from Google Play - it's neater.
• Fast Dormancy Toggle for i9300 - to improve battery life due to iffy VF data connections
• Freenote - for detailed notes (install it - superb piece of software)

Being left-handed, I also struggled with the fact that CM has no configuration for changing the dominant hand ;

Use:

for left hand dominant

and

for right-hand dominant.

Just save this as a script in /data/local/userinit.sh so that it is loaded at boot-time.

And ... I'm very happy with my beast of a smartphone.