hmm.. no, my rightmost icon is Skype, which I use often.. never a problem. But there were some threads about screen sensitivity problems near the right edge, I'm not affected so I don't know if that would be software or hardware.. on the other hand you said that it sometimes triggered the leftmost icon, that sounds more like a simple-launcher problem. Could be that it depends on the size of the icon - the Skype icon is fairly large.

BTW my version of simple-launcher is 0.9.5, for OS2007.