I think that all of the suggestions made so far require you to install scratchbox and have/learn a lot of scratchbox/Hildon/Linux/GTK knowledge. Is this true? If so, are there any real alternatives out there? This is what I have found so far: There was a project called Eagle that looked promising: http://www.gustavobarbieri.com.br/eagle/ but I don't think it has been made available for OS2008. Anybody know what is happening to Eagle? Another alternative is to install a local cgi web-server and write your app as a combination of browser-resident Javascript and Python cgi. You could use json-rpc or xml-rpc to communate between the js and python code. This is the approach that I am planning to use unless someone tells me not to bother and gives me a good reason why it won't work. Or gives me a better alternative. I think that something like the old HyperCard (68K Mac app) would be real nice on a tablet.