I second the request to send control commands to Girder http://www.promixis.com/, which can then do a myriad of things like send IR (single or complex macros), control home automation equipment, trigger events in Windows, etc.

I've been using a custom web interface that sends Ajax commands to Girder running on a small Windows PC and it works fairly well, but button layout is a pain and there are limitations (like having to hack support for the hard buttons, or no real press-and-hold repeat capability as that brings up the context menu in microb).

Irreco looks like an amazing alternative if the control portion could be implemented. Girder's web service is as simple as a GET call with two parameters (device name, command name), or I believe there's a port open for more direct command execution via TCP/IP.