I have used various skyscape programs which have all worked ok. You might well run into trouble with calculator programs as they may depend on mathlib.prc which causes problems. I use medcalc on my treo and it appears to run fine on my n800 until you try to calculate anything when you get nonsense. So really you have to try and see. The other thing to remember is your are limited to main storage in your Garnet emulator - no SD card so you can only install so much. I found things were much more stable when I started running off an OS cloned to the sd card which gives you more memory on the N800 for programs.