BURN THEM TO USB .... BURN THEM TO DVD ...RUN THEM....USE THEM.... do have the ability for persistence.. to remember and keep your work.
JUST for starters...
that is just one method to implement these iso's...
they are LIVE rolling release distro's with everything meant for work on the nxx0 line packed in ready to 1 click use ...no set up (shy of scratchbox which is just too big to have ready to use inside a 4gb distro iso ...but once burned to say ...a usb flash drive..well the process is there inside as well to start the installation of scratch.)
The whole of it is just burn, run, play.
The intent here was to AVOID the overhead of VM's...
You don't have to run it in a VM...
unless that is your thing...
I don't use it in a vm ... not interested...
I have it installed on a couple of comps.
I have it installed on a whack of 32 gb and up.. flash drives...

Please do not confuse what it is or does....
If what you need is something completely different than a full nxx0 workshop with programs tailored for the device line inside ...pre-set up and ready to use..... then I wish you the best in making whatever it is ...happen...