I've read a great deal on the topic of humanity and technology...
Took such topics in philosophy.

Nothing will change.

The "Medium" sentience takes... means very very little.

Environment and appro stimuli mean everything.

There are only two factors which will impact negatively on humanity regardless of bio alteration.

1- who "controls' the input of stimuli.
( what deliberate omissions and censorship that will occur which may stunt, hamper, or hinder development)

2- the disappearance of native species.
( ecological diversity being paramount for sentient well being. )