If you've got the interest and time, please do

I've installed glade (2?) on ubuntu and used glade in gtk/c# app. Glade is real cool but i dont know how to use from python.

On the desktop side most of what you would do looks like this (ignoring mono stuff) :
http://nat.org/demos/gtksharp.html

Obviously python/glade would be the environment of choice of something like this though.