Nope. I got my N800 new from amazon, and the screen is as unprotected as it was. It did get some abuse from my 4 year old son, though

I'm running the latest Diablo on both.

From what I remember, the N800 was as insensitive as it is from the beginning, regardless of operating system or settings. I'm starting to believe this is a defect in my particular device, or batch of devices. I got another N800 at the time from amazon which I sent back after a few days because of a stain on the screen, and I don't remember it being any different. I think I would have noticed the difference in the second device which I kept, if there had been one. And a co-worker who also owned an N800 was amazed by how unresponsive my N800 was when I let him try kinetic webkit scrolling some weeks ago, saying his had been much better.

Of course I could be wrong and it actually degraded over time without me noticing. I certainly used the N800 a lot, so it's definitely well worn.