You could keep the same hardware configuration and move the 3 buttons on the left to the right side (or the directional pad, take your pick), make them a little larger/more durable and implement screen rotation. Heck, you could even split up the +/- keys on the top left/right edges and make for some additional gaming buttons.

Screen rotation would be great even if it was a simple screen button to switch from landscape to portrait (or inverted landscape).

Most of all, I want a scroll wheel. My screen protector has a nice clean worn-out vertical line from all the stylus scrolling I've been doing. At least on the browser you can grab the page instead of just the scroll bar.

You can get to a point where you're trying to be everything to everyone and not be good at anything. I'd be fine with streamlining it to be an improved Internet Tablet and stick with mouse/stylus games.