I tried rebooting, still no movement.

For what it's worth, I do have the upgraded in-program download version of U4, and here are the options I have checked on in the rubybox settings:

Basic:

cpu cycles max
render frameskip 4
sdl fullscreen true

advanced:

dos keyboardlayout auto
dos keyboardlayoutfile auto
mixer prebuffer 400
sdl autolock false
sdl mapperfile /home/user/.rubybox/.mappers/mapper72.txt


I tried it with and without the keyboardlayout options enabled, niether made a difference. : /