Nothing, or almost nothing, suits my needs anymore too much data to parse hence Winamp-like interface doesn't cut it anymore. None of the iTunes-like interfaces are good enough. amaroK 1.x was interesting, but I don't run KDE and don't like the 2.x roadmap. There is also the issue of integrating between different desktop (and mobile) clients. For now, I'm using Rhythmbox + PulseAudio, and I'm moderate content.