Count me up as another one who likes the current setup. I like the unlock key on the right-hand side (right hand, because landscape mode is the primary mode for this device). The unlock button has to be dragged down, which is less accident prone (in a pocket) than if it was enough to just press the key on the top.

USB on the left hand side I have no problems with. The device is on the table almost all day, and using it as an actual phone is a tiny fraction of the day. So to optimize for the latter isn't much of a point, the way I see it. If the USB connector was moved to the other side then something there would have to move to the opposite side, and I don't want the unlock button on the left - I use it all the time, and USB only rarely. That the current USB location should be 'optimized' for left handers I don't agree with - it's the opposite: Used rarely, therefore on the left.