Can you disable it? Of course. In fact if I'm not mistaken red pill automatically disables when you close the Application manager now.

Should you? well... there's a couple threads around here regarding that.. and it has been said that Red Pill mode is being removed.

It is my personal opinion that, no, you should not enable red pill. If you need something that red pill gives you access to... you should know how to do it on the CLI - since Red Pill doesn't give you access to anything you don't already have access to if you know where to look/do.