Python compiles the modules on runtime. So apparently there is no need to precompile the modules.

If you want you can precompile (Byte-compile) the modules, which will speed up their loading time, but IMHO this should be done by the installer (at least it is handled this way in Gentoo ebuilds).

But you should avoid placing stuff in the .dep file which happened to be created during testing (like the .pyc files, backup files from editor etc...)

Cheers
Bjoern