Spoon is considered by some to be a possible direction for a future Squeak. It is very small and designed from the ground up to load modules(?) on demand possibly from a remote server. So you end up only with what you use, plus the base image of course. Beyond that I am not familiar with it.

For those with no knowledge of Squeak/Smalltalk it may help to think of it more like VMWare than python, java, etc. The "image" truly represents a virtualised machine and just like VMWare it retains full state between runs (assuming you "save" of course).