Otterbox is great for protection but is a little tough on your face if you use the phone as a phone without a headset. There is a slightly sharpend ridge on the raised front portion which the flesh of your face will grow to hate. Easy enough to use a headset instead.
The topcover forces larger fingers down when trying to press the keys in the top row of the keyboard. It does cause you to make more typos at first until you learn to adjust to it.
The silicone inside of the case does a tremendous job of preventing scratches and wear as well as absorbing impacts from drops.